Transcriptional Dysregulation in the Ureteric Bud Causes Multicystic Dysplastic Kidney by Branching Morphogenesis Defect
نویسندگان
چکیده
منابع مشابه
Semaphorin3a inhibits ureteric bud branching morphogenesis
Class 3 semaphorins are guidance proteins involved in axon pathfinding, vascular patterning and lung branching morphogenesis in the developing mouse embryo. Semaphorin3a (Sema3a) is expressed in renal epithelia throughout kidney development, including podocytes and ureteric bud cells. However, the role of Sema3a in ureteric bud branching is unknown. Here we demonstrate that Sema3a plays a role ...
متن کاملMolecular events involved in the morphogenesis of multicystic dysplastic kidney.
INTRODUCTION Wnt-1 is capable of inducing metanephric mesenchyme to undergo tubulogenesis. A relationship between the degree of cystogenesis and reduced E-cadherin (E-cad) expression was described. Syndecan-1 (Sdc-1) has a critical role in kidney development. MATERIALS AND METHODS Ten multicystic dysplastic kidneys (MCDKs) were stained with hematoxylin and eosin and immunohistochemistry was p...
متن کاملMulticystic dysplastic kidney.
We reviewed 29 cases of congenital multicystic dysplastic kidneys. Isolated renal pelvic atresia has an excellent prognosis but lower ureteral atresias are associated with a high incidence of contralateral renal disease and have a worse prognosis.
متن کاملMulticystic Dysplastic Kidney
Multicystic dysplastic kidney (MCDK) is a renal abnormality that contains multiple cysts of various shapes and sizes in the kidney. Unilateral MCDK is very common in children and usually is associated with other contralateral anomalies. There are a few different etiology theories that are being evaluated, but the origination is still uncertain. Although there is no cure for MCDK, there are a fe...
متن کاملProtein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney.
The human protein kinase X (PRKX) gene was identified previously as a cAMP-dependent serine/threonine kinase that is aberrantly expressed in autosomal dominant polycystic disease kidneys and normally expressed in fetal kidneys. The PRKX kinase belongs to a serine/threonine kinase family that is phylogenetically and functionally distinct from classical protein kinase A kinases. Expression of PRK...
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ژورنال
عنوان ژورنال: Journal of Urology
سال: 2015
ISSN: 0022-5347,1527-3792
DOI: 10.1016/j.juro.2014.08.122